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Phone:719-634-1484

Fax:719-635-8223

 

 
 

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Colorado Arms Repair
Henry Valenzano
1705 N. Chestnut St.
Colorado Springs, CO 80907
Phone 719-634-1484


    

 

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Following synaptic vesicle exocytosis, neurons retrieve the fused membrane by a process of endocytosis to provide a supply of vesicles for subsequent release and maintain the presynaptic active zone. Rod and cone photoreceptors use a specialized structure called the synaptic ribbon that enables them to sustain high rates of neurotransmitter release. They must also employ mechanisms of synaptic vesicle endocytosis capable of keeping up with release. While much is known about endocytosis at another retinal ribbon synapse, that of the goldfish Moncler Outlet Mb1 bipolar cell, less is known about endocytosis in photoreceptors. We used capacitance recording techniques to measure vesicle membrane fusion and retrieval in photoreceptors from salamander retinal slices. We found that application of brief depolarizing steps (<100 ms) to cones evoked exocytosis followed by rapid endocytosis with a time constant ∼250 ms. In some cases, the capacitance trace overshot the baseline, indicating excess endocytosis. Calcium had no effect on the time constant, but enhanced excess endocytosis resulting in a faster rate of membrane retrieval. Surprisingly, endocytosis was unaffected by blockers of dynamin, suggesting that cone endocytosis is dynamin independent. This contrasts with synaptic vesicle endocytosis in rods, which was inhibited by the dynamin inhibitor dynasore and GTPγS introduced through the patch pipette, suggesting that the two photoreceptor types employ distinct pathways for vesicle retrieval. The fast kinetics of synaptic vesicle endocytosis in photoreceptors likely enables these cells to maintain a high rate of transmitter release, allowing them to faithfully Moncler Women Jackets signal changes in illumination to second-order neurons.  




Inspecting & troubleshooting Strip Clean & Inspect
Accuracy tuning Smoothing and tuning a revolver action
Sight Installation & Adjustments Stock repair or replacement
Choke Installation Swivel installation
Repairs to receiver Recoil pad replacement
Trigger Assy. repair / fitting Bedding a barrel / action
FFL Transfers Repair or replace firing pin
  Repairs to safety
  Colors Bluing
FFL Transfers are now $30.00 per firearm

 

 

 

Hours:

Tuesday 9:am- 6:pm

Wed 9:am - 6:pm

Thurs 9:am - 6:pm

Friday 9:am - 6:pm

Saturday 9:am - 5:pm

Sunday : Closed

Monday : Closed

 
         

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